VIP (Vasoactive Intestinal Peptide)
Also known as: vasoactive intestinal peptide, VIP
By GLPeptideSciences Editorial Team · How we evaluate evidence · Reviewed by Dr. George S. Watson, MD, Cardiothoracic Surgeon · Updated 2026-06-02
A naturally occurring signaling neuropeptide with broad roles in immune and inflammatory regulation, discussed in chronic-inflammation and gut contexts.
What it is & how it works
What it is
VIP is a vasoactive intestinal peptide — a signaling molecule the body produces naturally, with wide-ranging roles in immune regulation, vascular tone and the gut and lungs.
How it is thought to work
It acts on VPAC receptors and modulates inflammatory and immune signaling. That broad role is why it appears in discussions of chronic inflammatory conditions.
The evidence and the caveat
The basic biology is well documented, but the specific protocols discussed in the community have limited clinical validation. Because VIP affects vascular tone, it isn’t a casual compound.
What it's discussed & studied for
- Inflammation and immune modulation
- Chronic inflammatory response / CIRS discussion
- Gut and respiratory discussion
Discussion of a use is not a claim that it works or is approved.
Research status
A real endogenous peptide with substantial basic-science literature; targeted therapeutic use (e.g., intranasal protocols) is investigational and not broadly approved.
Evidence quality
Strong basic biology, but clinical evidence for the specific protocols discussed in the community is limited. Read protocol-level claims cautiously.
Dosing discussion
Intranasal protocols are discussed in specific clinical contexts; there is no broadly validated consumer dose.
Educational summary of what is discussed in the literature and community — not a dosing recommendation or medical advice.
Safety & harm reduction
Can affect blood pressure and vascular tone given its physiological role; not a casual compound. Human safety outside studied settings is not well characterized.
Sourcing literacy
Compounded forms exist in some clinical settings; research-market material is unverified.
Selected literature
FAQ
Is VIP a drug?
It's an endogenous signaling peptide. Specific therapeutic protocols are investigational rather than broadly approved.