KPV
Also known as: Lys-Pro-Val, α-MSH(11-13)
By GLPeptideSciences Editorial Team · How we evaluate evidence · Reviewed by Dr. George S. Watson, MD, Cardiothoracic Surgeon · Updated 2026-06-02
A three-amino-acid fragment of α-MSH studied for anti-inflammatory activity, particularly in the gut, largely in preclinical models.
What it is & how it works
What it is
KPV is a tripeptide — just three amino acids (lysine-proline-valine) — corresponding to the tail end of the hormone α-MSH. That small fragment carries much of α-MSH’s anti-inflammatory activity without its pigmentation effects.
How it is thought to work
In preclinical models it appears to dampen inflammatory signaling (including NF-κB pathways), with particular interest in the gut, where it has been studied in models of intestinal inflammation.
The evidence and the caveat
The anti-inflammatory rationale is reasonable and the preclinical data is supportive, but human trial evidence is sparse. It’s often stacked with BPC-157 in community recovery discussion — that’s anecdotal practice, not validated protocol.
What it's discussed & studied for
- Inflammation modulation (preclinical)
- Gut / inflammatory bowel discussion
- Skin and wound discussion (anecdotal)
Discussion of a use is not a claim that it works or is approved.
Research status
Investigational. Evidence is predominantly animal and cell-based. Not approved for any use.
Evidence quality
Plausible anti-inflammatory mechanism with supportive preclinical data, but little human trial evidence. Read claims as preclinical.
Dosing discussion
No approved or validated human protocol exists. Oral and injectable use are both discussed in the community without trial-grade dosing data.
Educational summary of what is discussed in the literature and community — not a dosing recommendation or medical advice.
Safety & harm reduction
Generally described as well tolerated in preclinical work, but human safety data is limited. Limited data is not the same as established safety.
Sourcing literacy
No approved product; research-market KPV is unverified, with identity and purity risks.
Selected literature
FAQ
What is KPV derived from?
It's the C-terminal tripeptide (lysine-proline-valine) of α-MSH, the part associated with much of its anti-inflammatory activity.
Is there human evidence for KPV?
Very little. Most of the supporting research is animal and cell-based; it is not approved.