Humanin
Also known as: HN, mitochondrial-derived peptide
By GLPeptideSciences Editorial Team · How we evaluate evidence · Reviewed by Dr. George S. Watson, MD, Cardiothoracic Surgeon · Updated 2026-06-02
A mitochondrial-derived peptide studied for cytoprotective, metabolic and neuroprotective effects, largely in preclinical models.
What it is & how it works
What it is
Humanin is a mitochondrial-derived peptide, in the same broad family as MOTS-c, studied as a cytoprotective signaling molecule.
How it is thought to work
It’s associated with protecting cells from stress and apoptosis and with metabolic and neuroprotective signaling, which is why it appears in aging research.
The evidence and the caveat
The basic biology is real and active, but human therapeutic data is limited. Longevity-level claims are preclinical, not established outcomes.
What it's discussed & studied for
- Cytoprotection and metabolic regulation (preclinical)
- Neuroprotection and aging research
Discussion of a use is not a claim that it works or is approved.
Research status
Investigational. A genuine endogenous peptide with active basic-science interest; human therapeutic data is limited. Not approved.
Evidence quality
Strong basic biology, limited human outcome data. Read longevity claims as preclinical.
Dosing discussion
No validated human protocol exists; anything discussed is extrapolated.
Educational summary of what is discussed in the literature and community — not a dosing recommendation or medical advice.
Safety & harm reduction
Human safety as an administered compound is not well characterized.
Sourcing literacy
No approved product; research-market material is unverified.
Selected literature
FAQ
What is humanin?
It's a small peptide encoded in mitochondrial DNA, studied as a cytoprotective signaling molecule — mostly in preclinical research.